Symbol
Name
ID

Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
MGI:98483

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Chronic sinusitis	Chronic otitis media	Acute infectious pneumonia	Autoimmunity	Asthma	Recurrent Haemophilus influenzae infections	Bronchiolitis	Recurrent lower respiratory tract infections	Recurrent bronchitis
Disease(s) Associated with TAP1	Chronic sinusitis	Chronic otitis media	Acute infectious pneumonia	Autoimmunity	Asthma	Recurrent Haemophilus influenzae infections	Bronchiolitis	Recurrent lower respiratory tract infections	Recurrent bronchitis
asthma
bronchiectasis
MHC class I deficiency
type 1 diabetes mellitus

Mouse Phenotypes

immune system phenotype

decreased double-negative T cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased T-helper 1 cell number

decreased CD8-positive, alpha-beta memory T cell number

decreased CD8-positive, alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

abnormal lymphocyte physiology

decreased cytotoxic T cell cytolysis

abnormal dendritic cell antigen presentation

abnormal antigen presentation

abnormal antigen presentation via MHC class I

decreased level of surface class I molecules

defective assembly of class I molecules

defective intracellular transport of class I molecules

decreased susceptibility to bacterial infection

decreased susceptibility to bacterial infection induced morbidity/mortality

increased susceptibility to Herpesvirales infection

Availability

Mouse Genotype

Tap1^m1Btlr/Tap1^m1Btlr

Tap1^m2Btlr/Tap1^m2Btlr

Tap1^rose/Tap1^rose

Tap1^tm1Arp/Tap1^tm1Arp

Tap1^tm1Hpl/Tap1^tm1Hpl

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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